Notch receptors are clustered and trans-endocytosed by Delta ligand cells. Confocal micrograph of a Delta expressing cell (left) interacting with a Notch expressing cell (right). Following interaction with Delta (blue), cell surface Notch (yellow) is clustered at cell-cell interfaces. Notch extracellular domain is detected within Delta cells (green) indicative of trans-endocytosis. Endocytosis of ligand while bound to Notch may produce a force sufficient to pull Notch apart and activate signaling.
 
 
 
 
 
 

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February 2010 - Vol. 11 Issue 2 Page 175-301

Review Article

Divide et Impera: The Dictum of Peroxisomes

Shirisha Nagotu, Marten Veenhuis and Ida J. van der Klei
pages 175 - 184

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Original Articles

Nap1 and Chz1 have Separate Htz1 Nuclear Import and Assembly Functions

Korinna Straube, Jeffrey S. Blackwell and Lucy F. Pemberton
pages 185 - 197

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Nap1 and Chz1 have Separate Htz1 Nuclear Import and Assembly Functions

Korinna Straube, Jeffrey S. Blackwell and Lucy F. Pemberton
pages 185 - 197

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The Nuclear Import of the Small GTPase Rac1 is Mediated by the Direct Interaction with Karyopherin α2

Kirstin Sandrock, Heike Bielek, Kristina Schradi, Gudula Schmidt and Norbert Klugbauer
pages 198 - 209

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Efficient Internalization of MHC I Requires Lysine-11 and Lysine-63 Mixed Linkage Polyubiquitin Chains

Jessica M. Boname, Mair Thomas, Helen R. Stagg, Ping Xu, Junmin Peng and Paul J. Lehner
pages 210 - 220

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Rab10 Regulates Phagosome Maturation and Its Overexpression Rescues Mycobacterium-Containing Phagosomes Maturation

Carla M. P. Cardoso, Luisa Jordao and Otilia V. Vieira
pages 221 - 235

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Trafficking of the Phosphoprotein PfCRT to the Digestive Vacuolar Membrane in Plasmodium falciparum

Yvonne Kuhn, Cecilia P. Sanchez, Daniel Ayoub, Theodora Saridaki, Alain van Dorsselaer and Michael Lanzer
pages 236 - 249

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Masking of Transmembrane-Based Retention Signals Controls ER Export of γ-Secretase

Matthias Fassler, Michael Zocher, Sebastian Klare, Alerie Guzman de la Fuente, Johanna Scheuermann, Anja Capell, Christian Haass, Christina Valkova, Anbazhagan Veerappan, Dirk Schneider and Christoph Kaether
pages 250 - 258

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GGA Autoinhibition Revisited

Jacob F. Cramer, Camilla Gustafsen, Manja A. Behrens, Cristiano L. P. Oliveira, Jan Skov Pedersen, Peder Madsen, Claus Munck Petersen and Søren S. Thirup
pages 259 - 273

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Thiazolidinediones Induce Rab7–RILP–MAPK-Dependent Juxtanuclear Lysosome Aggregation and Reduce Tumor Cell Invasion

Joshua J. Steffan and James A. Cardelli
pages 274 - 286

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Multiple Primary Cilia Modulate the Fluid Transcytosis in Choroid Plexus Epithelium

Keishi Narita, Toyoko Kawate, Naoto Kakinuma and Sen Takeda
pages 287 - 301

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