Notch receptors are clustered and trans-endocytosed by Delta ligand cells. Confocal micrograph of a Delta expressing cell (left) interacting with a Notch expressing cell (right). Following interaction with Delta (blue), cell surface Notch (yellow) is clustered at cell-cell interfaces. Notch extracellular domain is detected within Delta cells (green) indicative of trans-endocytosis. Endocytosis of ligand while bound to Notch may produce a force sufficient to pull Notch apart and activate signaling.
 
 
 
 
 
 

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August 2010 - Vol. 11 Issue 8 Page 1017-1118

Original Articles

Exit of GPI-Anchored Proteins from the ER Differs in Yeast and Mammalian Cells

Anne-Sophie Rivier, Guillaume A. Castillon, Laetitia Michon, Masayoshi Fukasawa, Maria Romanova-Michaelides, Nina Jaensch, Kentaro Hanada and Reika Watanabe
pages 1017 - 1033

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Genetic Analysis of Yeast Sec24p Mutants Suggests Cargo Binding Is Not Co-operative during ER Export

Roy Buchanan, Andrew Kaufman, Leslie Kung-Tran and Elizabeth A. Miller
pages 1034 - 1043

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Role of the Lectin VIP36 in Post-ER Quality Control of Human α1-Antitrypsin

Veronika Reiterer, Beat Nyfeler and Hans-Peter Hauri
pages 1044 - 1055

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MAL2 Selectively Regulates Polymeric IgA Receptor Delivery from the Golgi to the Plasma Membrane in WIF-B Cells

Julie G. In and Pamela L. Tuma
pages 1056 - 1066

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Cdc42 Regulates Microtubule-Dependent Golgi Positioning

Heidi Hehnly, Weidong Xu, Ji-Long Chen and Mark Stamnes
pages 1067 - 1078

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Pak1 Phosphorylation Enhances Cortactin–N-WASP Interaction in Clathrin-Caveolin-Independent Endocytosis

Alexandre Grassart, Vannary Meas-Yedid, Alexandre Dufour, Jean-Christophe Olivo-Marin, Alice Dautry-Varsat and Nathalie Sauvonnet
pages 1079 - 1091

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Oligomeric Dop1p is Part of the Endosomal Neo1p-Ysl2p-Arl1p Membrane Remodeling Complex

Sónia Barbosa, Dagmar Pratte, Heinz Schwarz, Rüdiger Pipkorn and Birgit Singer-Krüger
pages 1092 - 1106

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Protein Kinase D1 Regulates VEGF-A-Induced αvβ3 Integrin Trafficking and Endothelial Cell Migration

Laura di Blasio, Sara Droetto, Jim Norman, Federico Bussolino and Luca Primo
pages 1107 - 1118

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Microbiology

The cell biology of microbes as well as effects of the microbial pathogens on the host cell have provided exciting and unique insights for cell biologists, and TRAFFIC has become a premier journal for the publication of papers reporting new discoveries in this field. The most recent TRAFFIC papers on all aspects of microbiology will now be collected together as TRAFFIC - MICROBIOLOGY.

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