Aims and Scope - Traffic the International Journal of Intracellular Transport

Notch receptors are clustered and trans-endocytosed by Delta ligand cells. Confocal micrograph of a Delta expressing cell (left) interacting with a Notch expressing cell (right). Following interaction with Delta (blue), cell surface Notch (yellow) is clustered at cell-cell interfaces. Notch extracellular domain is detected within Delta cells (green) indicative of trans-endocytosis. Endocytosis of ligand while bound to Notch may produce a force sufficient to pull Notch apart and activate signaling.

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Aims and Scope

Edited by:
Mark C. P. Marsh, Gerrit van Meer, Trina A. Schroer, Tom H. Stevens

Print ISSN: 1398-9219
Online ISSN: 1600-0854
Frequency: Monthly
Current Volume: 11 / 2010
ISI Journal Citation Reports® Ranking: 2009: Cell Biology: 30 / 161
Impact Factor: 6.255

Traffic covers the cell biology and biochemistry of intracellular transport in health and disease and aims to publish manuscripts at the forefront of this field. Specific topics of focus include membrane protein and lipid traffic, intracellular motility, protein transport across membranes, membrane protein assembly and degradation, antigen processing, and the structure, function and regulation of molecules involved in these pathways. Infectious and hereditary diseases with intracellular pathogenesis affecting these processes are also a major focus.

Traffic publishes cutting-edge research and review articles dealing with structural biology, cell biology, protein biochemistry, molecular biology, morphology, intracellular signalling and genetic and infectious diseases in the following areas, for mammalian and non-mammalian systems:

Membrane protein and lipid traffic
Organelle movement and biogenesis
Nuclear transport
Protein translocation
Antigen processing and presentation
Viral and cellular pathogens
Intracellular proteolysis
Cytokinesis/Cell cycle
Molecular motors