Notch receptors are clustered and trans-endocytosed by Delta ligand cells. Confocal micrograph of a Delta expressing cell (left) interacting with a Notch expressing cell (right). Following interaction with Delta (blue), cell surface Notch (yellow) is clustered at cell-cell interfaces. Notch extracellular domain is detected within Delta cells (green) indicative of trans-endocytosis. Endocytosis of ligand while bound to Notch may produce a force sufficient to pull Notch apart and activate signaling.
 
 
 
 
 
 

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Editors

Mark C. P. Marsh
MRC Laboratory for Molecular Cell Biology
University College London
Gower Street
London WC1E 6BT
UK
m.marsh@ucl.ac.uk

Gerrit van Meer
Institute of Biomembranes
University of Utrecht
Kruyt Building, Room N-607
Padualaan 8
3584 CH Utrecht
The Netherlands
g.vanmeer@uu.nl

Trina A. Schroer
220 A Mudd Hall
The Johns Hopkins University
3400 N. Charles St.
Baltimore, MD 21218
USA
schroer@jhu.edu

Tom H. Stevens
Institute of Molecular Biology
University of Oregon
Eugene, OR 97403-1229
USA
stevens@molbio.uoregon.edu


Associate Editors
Bruno Goud, Paris, France
Gillian M. Griffiths, Cambridge, UK
Carolyn E. Machamer, Baltimore, MD, USA
Michael S. Marks, Philadelphia, PA, USA
Robert G Parton, Queensland, Australia
Murray Stewart, Cambridge, UK

Review Consultant
Frances Brodsky, San Francisco, USA

Editorial Board
Viki Allan, Manchester, UK
Gerard Apodaca, Pittsburgh, PA, USA
Allesandra d'Azzo, Memphis, TN, USA
William E. Balch, La Jolla, CA, USA
Vytas A. Bankaitis, Chapel Hill, NC, USA
Janice S. Blum, Indianapolis, IN, USA
Nia Bryant, Glasgow, United Kingdom
Brian Burke, Gainesville, FL, USA
Elizabeth Conibear, Vancouver, Canada
Anita Corbett, Atlanta, GA, USA
Peter Cresswell, New Haven, CT, USA
Esteban Dell'Angelica, Los Angeles, CA, USA
Stephen Doxsey, Worcester, MA, USA
Rainer Duden, London, UK
Mark C. Field, Cambridge, United Kingdom
Reid Gilmore, Worcester, MA, USA
Benjamin S. Glick, Chicago, IL, USA
Marcos Gonzalez-Gaitan, Geneva, Switzerland
Gisou van der Goot, Lausanne, Switzerland
Sergio Grinstein, Toronto, Canada
Jean E. Gruenberg, Geneva, Switzerland
Kentaro Hanada, Tokyo, Japan
Chris Hawes, Oxford, United Kingdom
Nobutaka Hirokawa, Tokyo, Japan
Wanjin Hong, Singapore
Kathryn E. Howell, Denver, CO, USA
David E. James, Sydney, Australia
Ludger Johannes, Paris, France
Judith Klumperman, Utrecht, The Netherlands
Akihiro Kusumi, Kyoto, Japan
Alberto Luini, S. Maria Imbaro, Italy
J. Paul Luzio, Cambridge, UK
Satyajit Mayor, Bangalore, India 
Mary Munson, Worcester, USA
Christopher Nicchitta, Durham, NC, USA
Jodi J. Nunnari, Davis, CA, USA
Hiroshi Ohno, Kanazawa, Japan
Richard E. Pagano, Rochester, MN, USA
Gregory S. Payne, Los Angeles, CA, USA
Lucy F. Pemberton, Charlottesville, VA, USA
Susan K. Pierce, Rockville, MD, USA
Robert C. Piper, Iowa City, IA, USA
Graça Raposo, Paris, France 
Margaret S. Robinson, Cambridge, UK
Enrique Rodriguez-Boulan, New York, NY, USA
Michael G. Roth, Dallas, TX, USA
David G. Russell, Ithaca, NY, USA
Giampietro Schiavo, London, UK
Janet Shaw, Salt Lake City, UT, USA
Kai Simons, Dresden, Germany
Beate Sodeik, Hannover, Germany
Dominique Soldati-Favre, Genève, Switzerland
Alexander Sorkin, Denver, CO, USA
Olivia Steele-Mortimer, Hamilton, MT, USA
Harald Stenmark, Oslo, Norway
Jennifer L. Stow, Brisbane, Australia
Stanley R. Terlecky, Detroit, MI, USA
Sharon A. Tooze, London, UK
Linton M. Traub, Pittsburgh, USA
Beverly Wendland, Baltimore, MD, USA
Susan R. Wente, Nashville, TN, USA
Alpha Yap, Brisbane, Australia
Marino Zerial, Dresden, Germany


 

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