Notch receptors are clustered and trans-endocytosed by Delta ligand cells. Confocal micrograph of a Delta expressing cell (left) interacting with a Notch expressing cell (right). Following interaction with Delta (blue), cell surface Notch (yellow) is clustered at cell-cell interfaces. Notch extracellular domain is detected within Delta cells (green) indicative of trans-endocytosis. Endocytosis of ligand while bound to Notch may produce a force sufficient to pull Notch apart and activate signaling.
 
 
 
 
 
 

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Faculty of 1000
 
 

Faculty of 1000 Biology is an award-winning online service that highlights and evaluates the most interesting papers published in the biological sciences, based on the recommendations of over 2000 of the world's top researchers.

The following recently published articles in Traffic have been evaluted and rated by Faculty of 1000:

Trafficking of MHC Class II in Dendritic Cells is Dependent on but Not Regulated by Degradation of Its Associated Invariant Chain
Toine ten Broeke, Anko de Graaff, Esther M. van't Veld, Marca H. M. Wauben, Willem Stoorvogel and Richard Wubbolts
F1000 Factor 6.0 (Must Read)

Grab a Golgi: Laser Trapping of Golgi Bodies Reveals in vivo Interactions with the Endoplasmic Reticulum
Imogen A. Sparkes, Tijs Ketelaar, Norbert C.A. de Ruijter, Chris Hawes
F1000 Factor 6.0 (Must Read)

Bulk Flow Revisited: Transport of a Soluble Protein in the Secretory Pathway
Friederike Thor, Matthias Gautschi, Roger Geiger, Ari Helenius
F1000 Factor 3.0 (Recommended)

High-Resolution Fractionation of Signaling Endosomes Containing Different Receptors
Gretchen McCaffrey, Jonathan Welker, Jessica Scott, Louise van der Salm, Mark L. Grimes
F1000 Factor 3.0 (Recommended)

Vesicle Motion and Fusion are Altered in Chromaffin Cells with Increased SNARE Cluster Dynamics Inmaculada López, Jose A. Ortiz, José Villanueva, Vanesa Torres, Cristina J. Torregrosa-Hetland, Maria del Mar Francés, Salvador Viniegra, Luis M. Gutiérrez
F1000 Factor 3.0 (Recommended)

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