Notch receptors are clustered and trans-endocytosed by Delta ligand cells. Confocal micrograph of a Delta expressing cell (left) interacting with a Notch expressing cell (right). Following interaction with Delta (blue), cell surface Notch (yellow) is clustered at cell-cell interfaces. Notch extracellular domain is detected within Delta cells (green) indicative of trans-endocytosis. Endocytosis of ligand while bound to Notch may produce a force sufficient to pull Notch apart and activate signaling.
 
 
 
 
 
 

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Here are the cover illustrations of volume 11 issues. Please click the appropriate link to view the illustrations of previous volumes:

Cover Image
Vol.11 Iss.3, March 2010

Cover Legend: The structures of the COPII cage and coat. The image was created using Cinema 4D and the COPII volumes from the EMDB accession numbers 1232 and 1511. Image courtesy of Scott Stagg and Jason O'Donnell (see Russell and Stagg. Traffic 2010; 11(3):XXX-XXX).
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Cover Image
Vol.11 Iss.2, February 2010

Cover Legend:Freshly isolated PCPECs expressed clusters of primary cilia. (Top) A high magnification SEM image of PCPEC cells have clusters of cilia expressed on the apical surface. (Bottom) Representative high magnification images of PCPEC primary cilia. The leftmost panel depicts a proximal segment, whereas the others are distal segments. See Narita et al. Traffic 2010; 11(2): XXX-XXX.
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Cover Image
Vol.11 Iss.1, January 2010

Cover Legend: Celebrating 10 years of Publication: Complete legends for each cover image can be found in the "Cover Gallery" (http://www.traffic.dk/photo_gallery.asp). From top left to bottom right, the covers are from 6(5), 1(7), 1(8), 3(8), 5(7), 3(11), 1(1), 3(12), 9(6), 5(2), 3(1), 3(4), 2(3), 3(6), 3(9), 4(8), 5(3), 5(9), 5(12), 6(2), 6(1), 6(3), 6(4), 6(6), 4(3), 6(12), 7(1), 7(5), 7(8), 7(10), 7(12), 8(4), 8(2), 9(9), 9(8), 9(3), 9(4), 9(10), 10(2), 10(3), 10(6), 10(4), 10(11).
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