Notch receptors are clustered and trans-endocytosed by Delta ligand cells. Confocal micrograph of a Delta expressing cell (left) interacting with a Notch expressing cell (right). Following interaction with Delta (blue), cell surface Notch (yellow) is clustered at cell-cell interfaces. Notch extracellular domain is detected within Delta cells (green) indicative of trans-endocytosis. Endocytosis of ligand while bound to Notch may produce a force sufficient to pull Notch apart and activate signaling.
 
 
 
 
 
 

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Volume 7 issue 5 May 2006
Clathrin is Important for Normal Actin Dynamics and Progression of Sla2p Containing Patches During Endocytosis in Yeast
Thomas M. Newpher and Sandra K. Lemmon

Volume 7 issue 4 April 2006
A multigene family encoding R-SNAREs in the ciliate Paramecium tetraurelia
Christina Schilde, Thomas Wassmer, Joerg Mansfeld , Helmut Plattner, and Roland Kissmeh

Volume 7 issue 2 February 2006
Dynamics of Membrane Clathrin-Coated Structures during Cytokinesis
Anne K. Warner, James H. Keen and Yu-li Wang

Volume 7 issue 2 February 2006
Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes
Robert Köchl, Xiao Wen Hu, Edmond Y. W. Chan, Sharon A. Tooze

Volume 7 issue 1 January 2006
Dynamics of MAL2 During GPI-anchored Protein Transcytotic Transport to the Apical Surface of Hepatoma HepG2 Cells
María C. de Marco, Rosa Puertollano, José A. Martínez-Menárguez and Miguel A. Alonso

Volume 6 issue 12 December 2005
Differential CD91 Dependence for Calreticulin and Pseudomonas Exotoxin-A Endocytosis
Julie Jo Walters and Brent Berwin

Volume 6 issue 12 December 2005
E-cadherin transport from the TGN in tubulovesicular carriers is selectively regulated by golgin-97
John G. Lock, Luke A. Hammond, Fiona Houghton, Paul A. Gleeson and Jennifer L. Stow

Volume 6 issue 12 November 2005
Human eosinophils secrete preformed, granule-stored interleukin-4 (IL-4) through distinct vesicular compartments
Rossana C. N. Melo, Lisa A. Spencer, Sandra A. C. Perez , Ionita Ghiran Ann M. Dvorak and Peter F. Weller

Volume 6 issue 10 October 2005
Intragranular vesiculotubular compartments are involved in piecemeal degranulation by activated human eosinophils
Rossana C. N. Melo, Sandra A. C. Perez, Lisa A. Spencer, Ann M. Dvorak and Peter F. Weller

Volume 5 issue 12 December 2004
3-D structure of multilaminar lysosomes in antigen presenting celss reveals trapping of MHC II on the internal membranes
Jean-Luc A. N. Murk, Misjaël N. Lebbink, Bruno M. Humbel, Willie J.C. Geerts, Janice M. Griffith, Dennis M.L. Langenberg, Frank A.W. Verreck, Arie J. Verkleij, Abraham J. Koster, Hans J. Geuze, Monique J. Kleijmeer

Volume 5 issue 11 November 2004
Molecular partitioning during host cell penetration by Toxoplasma gondii
Audra J. Charron and L. David Sibley

Volume 5 issue 10 October 2004
Temperature-sensitive random insulin granule diffusion is a prerequisite for recruiting granules for release.
Rosita Ivarsson, Stefanie Obermüller, Guy A. Rutter, Juris Galvanovskis and Erik Renström

Volume 5 issue 6 June 2004
VisBio: a Computational Tool for Visualization of Multidimensional Biological Image Data
C. Rueden, K. W. Eliceiri and J. G. White Laboratory for Optical and Computational Instrumentation University of Wisconsin-Madison

Volume 5 issue 6 June 2004
Requirement for the Rac GTPase in Chlamydia trachomatis Invasion of Non-phagocytic Cells
Rey A. Carabeo, Scott S. Grieshaber, Aaron Hasenkrug, Cheryl Dooley, and Ted Hackstadt

Volume 5 issue 5 May 2004
Predicting function from structure: 3D structure studies of the mammalian Golgi complex
Soren Mogelsvang, Brad J. Marsh, Mark S. Ladinsky and Kathryn E. Howell

Volume 5 issue 5 May 2004
Structure-Function Analysis on the Beach Protein LvsA
Wei-I Wu, Juhi Yajnik, Michael Siano, and Arturo De Lozanne

Volume 5 issue 4 April 2004
Golgi inheritance under a block of anterograde and retrograde traffic
Clément Nizak, Rachid Sougrat, Florence Jollivet, Alain Rambourg, Bruno Goud and Franck Perez

Volume 5 issue 1 January 2004
A karyopherin 2 nuclear transport pathway is regulated by glucose in hepatic and pancreatic cells
Aurélia CASSANY, Ghislaine GUILLEMAIN, Christophe KLEIN, Véronique DALET, Edith BROT-LAROCHE and Armelle LETURQUE

Volume 4 issue 12 December 2003
HIV-1 egress is gated through late endosomal membranes
Sascha Nydegger, Michelangelo Foti, Aaron Derdowski, Paul Spearman, Markus Thali

Volume 4 issue 11 November 2003
Visualization of retroviral replication in living cells reveals budding into multivesicular bodies
Nathan M. Sherer, Maik J. Lehmann, Luisa F. Jimenez-Soto, Alyssa Ingmundson, Stacy M. Horner, Gregor Cicchetti, Philip G. Allen, Marc Pypaert, James M. Cunningham, and Walther Mothes

Volume 4 issue 11 November 2003
Recombinant antibodies against subcellular fractions used to track endogenous Golgi protein dynamics in vivo
Clément Nizak, Silvia Martin-Lluesma, Sandrine Moutel, Aurélien Roux, Thomas E. Kreis, Bruno Goud and Franck Perez

Volume 4 issue 10 October 2003
Dynamics of the Apical Plasma Membrane Recycling System During Cell Division
Karen C. Hobdy-Henderson, Chadwick M. Hales, Lynne A. Lapierre, Richard E. Cheney and James R. Goldenring

Volume 4 issue 9 September 2003
Movies

Volume 4 issue 8 August 2003
Movie from a cluster of peroxisomes in a high-pressure frozen dendritic cell.
Henk F. Tabak, Jean L. Murk, Ineke Braakman and Hans J. Geuze

Volume 4 issue 7 July 2003
Movement of plasma membrane associated clathrin spots along the microtubule cytoskeleton
Joshua Z. Rappoport, Bushra W. Taha and Sanford M. Simon

Volume 4 issue 5 May 2003
Microtubule-dependent transport of secretory vesicles in RBL-2H3 cells
Alexander J. Smith, Janet R. Pfeiffer, Jun Zhang, A. Marina Martinez, Gillian M. Griffiths and Bridget S. Wilson

Volume 4 issue 3 March 2003
GAIP Participates in Budding of Membrane Carriers at the Trans-Golgi Network
Fiona G. Wylie, John G. Lock, Lubomira Jamriska, Tatiana Khromykh, Darren Brown and Jennifer L. Stow

Volume 4 issue 2 February 2003
A Kinetic proof-reading mechanism for Protein sorting
M Weiss and T. Nilsson

Volume 4 issue 1 January 2003
Membrane Traffic in Virtual Reality
François Képès

Volume 3 issue 11 November 2002, p. 791
Endosome Fusion and Microtubule-based Dynamics in the Early Endocytic Pathway of Dictyostelium
Margaret Clarke, Jana Köhler, John Heuser, and Günther Gerisch

Volume 3 issue 11 November 2002, page 801
Regulation of peptidergic vesicle mobility by secretagogues
CL Washburn, JE Bean, MA Silverman, MJ Pellegrino, PA Yates and RG Allen

Volume 3 issue 11 November 2002, p. 833
The transitional ER defines a boundary for quality control in the secretion of tsO45 VSV glycoprotein
Anna Mezzacasa and Ari Helenius

Volume 3 Issue 4 April 2002
Selective delivery of secretory cargo in Golgi-derived carriers of non-epithelial cells
A Rustom, M Bajohrs, C Kaether, P Keller, D Toomre, D Corbeil and H-H Gerdes

Volume 3 Issue 2 February 2002
Visualization of actin dynamics during macropinocytosis and exocytosis
E Lee and DA Knecht

Volume 3 Issue 1 January 2002
The Dictyostelium LvsA Protein is Localized on the Contractile Vacuole and is Required for Osmoregulation.
Noel J. Gerald*, Michael Siano and Arturo De Lozanne

Volume2 Issue 11 November 2001
Dynamics of leptomycin B-sensitive neucleocytoplasmic flux of parathyroid hormone-related protein.
MHC Lam, B Henderson, MT Gillespie and DA Jans

Volume 2 Issue 5 May 2001, pages 277-298
Vesicular and nonvesicular transport of phosphatidylcholine in polarized HepG2 cells
D Wüstner, S Mukherjee, FR Maxfield, P Müller and A Herrmann

Volume 2 Issue 5 May 2001, pages 336-346
The GRIP Golgi localisation domain of p230 is a specific targeting sequence for a population of trans-Golgi network derived vesicles
DL Brown, K Heimann, L Kjer-Nielsen, C van Vliet, JL Stow and PA Gleeson

Volume 2 Issue 5 May 2001, pages 347-357
Trafficking of yellow fluorescent protein tagged mu1 subunit of clathrin adaptor AP1 complex in living cells
F Huang, A Nesterov, RE Carter and A Sorkin

Volume 2 Issue 3 March 2001
Secretory and endocytic pathways converge in a dynamic endosomal system in a primitive protozoan
E Ghedin, A Debrabant, JC Engel and DM Dwyer

Volume 1 Issue 12 December 2000
Raising the speed limits for 4D fluorescence microscopy.
Hammond AT and Glick BS

Volume 1 Issue 11 November 2000
Actin Assembly at the Membrane controlled by ARF6
Schafer and Cooper

Volume1 Issue 6 June 2000
Apical and basolateral endocytic pathways of MDCK cells meet in acidic common endosomes distinct from a nearly-neutral apical recycling endosome
Exing Wang, Paul S. Brown, Benjamin Aroeti, Steven J. Chapin, Keith E. Mostov and Kenneth W. Dunn

Volume 1 Issue 3 March 2000
Trafficking and release of mycobacterial lipids in infected macrophages
WL Beatty, ER Rhoades, H-J Ullrich, D Chatterjee, JE Heuser and DG Russell

Volume 1 Issue 2 February 2000
Default membrane-volume sorting is followed by polar sorting in compartments preceding the apical recycling endosome of MDCK cells
Paul S. Brown, Exing Wang, Benjamin Aroeti, Steven J. Chapin, Keith E. Mostov and Kenneth W. Dunn

Instructions for viewing the videoclips
The video clips are in QuickTime format. If your computer does not support this format. Please visit http://www.apple.com/quicktime/ for further instructions on how to install a viewer in our computer.
The QuickTime viewer is free and distributed by Apple Computer, Inc.

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