Notch receptors are clustered and trans-endocytosed by Delta ligand cells. Confocal micrograph of a Delta expressing cell (left) interacting with a Notch expressing cell (right). Following interaction with Delta (blue), cell surface Notch (yellow) is clustered at cell-cell interfaces. Notch extracellular domain is detected within Delta cells (green) indicative of trans-endocytosis. Endocytosis of ligand while bound to Notch may produce a force sufficient to pull Notch apart and activate signaling.
 
 
 
 
 
 

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Volume 8 issue 10 October 2007
An essential quality control mechanism at the eukaryotic basal body prior to intraflagellar transport.
A Stephan, S Vaughan, MK Shaw, K Gull and PG McKean

Supplemental Table 1: Sources and versions of genomic data used in this paper.

Organism Source1 Version Web reference
Arabidopsis thaliana TAIR TAIR6_pep_20051108 www.arabidopsis.org/
Caenorhabditis elegans WormBase WS150 www.wormbase.org/
Chlamydomonas reinhardtii JGI v3.0 www.chlamy.org/
Drosophila melanogaster ENSEMBL BDGP4.2 www.ebi.ac.uk/ensembl/
Giardia lamblia GiardiaDB - www.mbl.edu/Giardia/
Homo sapiens ENSEMBL NCBI 36 www.ebi.ac.uk/ensembl/
Leishmania major geneDB v5 www.genedb.org/
Plasmodium falciparum geneDB 3D7 v2.1.1 www.genedb.org/
Schizosaccharomyces pombe geneDB - www.genedb.org/
Tetrahymena thermophila TGD Predictions_Aug_2004 www.ciliate.org/
Trypanosoma brucei geneDB v4 www.genedb.org/
Tetraodon nigroviridis genoscope - www.genoscope.cns.fr/
Strongylocentrotus purpuratus hgsc V2.1 www.hgsc.bcm.tmc.edu/
Toxoplasma gondii toxoDB V4.0 www.toxodb.org/

1 Source of data does not necessarily correlate with sequencing centre(s). See individual projects for full acknowledgements of participants.

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