Notch receptors are clustered and trans-endocytosed by Delta ligand cells. Confocal micrograph of a Delta expressing cell (left) interacting with a Notch expressing cell (right). Following interaction with Delta (blue), cell surface Notch (yellow) is clustered at cell-cell interfaces. Notch extracellular domain is detected within Delta cells (green) indicative of trans-endocytosis. Endocytosis of ligand while bound to Notch may produce a force sufficient to pull Notch apart and activate signaling.
 
 
 
 
 
 

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Volume 8 issue 5 May 2007
Ugo1p is a multi-pass transmembrane protein with a single carrier domain required for mitochondrial fusion
Emily M. Coonrod1, Mary Anne Karren2, and Janet M. Shaw2*

Figure 1: Ugo1p has limited primary sequence homology with members of the MCP family.  Alignment of Ugo1p with canonical members of the MCP family including S. cerevisiae AAC2, bovine AAC2, and bovine UCP2.  Carrier domains in the MCP family are boxed and shaded.  Boxes also highlight motifs in Ugo1p that are predicted to be carrier domains and are labeled above the primary sequence (PCD1, PCD2).  Solid line indicates TMD295-312.  Dashed line indicates PTMD470-500 (the MPEx program predicts the most likely transmembrane domain in this interval to be between residues 469-487 (51)).  (*) indicates identical residues, (:) denotes strongly similar residues, and (.)  indicates weakly similar residues.  Alignment was generated using the ClustalW program.

Figure 1 (jpg)

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