Notch receptors are clustered and trans-endocytosed by Delta ligand cells. Confocal micrograph of a Delta expressing cell (left) interacting with a Notch expressing cell (right). Following interaction with Delta (blue), cell surface Notch (yellow) is clustered at cell-cell interfaces. Notch extracellular domain is detected within Delta cells (green) indicative of trans-endocytosis. Endocytosis of ligand while bound to Notch may produce a force sufficient to pull Notch apart and activate signaling.
 
 
 
 
 
 

Home

Aims and Scope

Editors

Contacts

Table of Contents

Article Search

Accepted Articles

Early View

Virtual Issues

Faculty of 1000

Supplemental Material

Cover Gallery

Subscribe

Advertising

Links

 

 

 
Issue Table of Contents
 
 
April 2010 - Vol. 11 Issue 4 Page 419-578

Review Articles

Lipids on Trial: The Search for the Offending Metabolite in Niemann-Pick type C Disease

Emyr Lloyd-Evans and Frances M. Platt
pages 419 - 428

View the article


Exocytotic Vesicle Behaviour Assessed by Total Internal Reflection Fluorescence Microscopy

James G. Burchfield, Jamie A. Lopez, Katarina Mele, Pascal Vallotton and William E. Hughes
pages 429 - 439

View the article

Toolbox Articles

Selective Visualization of Fluorescent Sterols in Caenorhabditis elegans by Bleach-Rate-Based Image Segmentation

Daniel Wüstner, Ane Landt Larsen, Nils J. Færgeman, Jonathan R. Brewer and Daniel Sage
pages 440 - 454

View the article

Original Articles

TIP47 is Required for the Production of Infectious HIV-1 Particles from Primary Macrophages

Hélène Bauby, Sandra Lopez-Vergès, Guillaume Hoeffel, Delphine Delcroix-Genête, Katy Janvier, Fabrizio Mammano, Anne Hosmalin and Clarisse Berlioz-Torrent
pages 455 - 467

View the article


Modulation of Local PtdIns3P Levels by the PI Phosphatase MTMR3 Regulates Constitutive Autophagy

Naoko Taguchi-Atarashi, Maho Hamasaki, Kohichi Matsunaga, Hiroko Omori, Nicholas T. Ktistakis, Tamotsu Yoshimori and Takeshi Noda
pages 468 - 478

View the article


Glucosylceramide Biosynthesis is Involved in Golgi Morphology and Protein Secretion in Plant Cells

Su Melser, Brigitte Batailler, Martine Peypelut, Christel Poujol, Yannick Bellec, Valérie Wattelet-Boyer, Lilly Maneta-Peyret, Jean-Denis Faure and Patrick Moreau
pages 479 - 490

View the article


Comprehensive Screening for Novel Rab-Binding Proteins by GST Pull-Down Assay Using 60 Different Mammalian Rabs

Eiko Kanno, Koutaro Ishibashi, Hotaka Kobayashi, Takahide Matsui, Norihiko Ohbayashi and Mitsunori Fukuda
pages 491 - 507

View the article


Regulation of P2Y1 Receptor Traffic by Sorting Nexin 1 is Retromer Independent

Shaista Nisar, Eamonn Kelly, Pete J. Cullen and Stuart J. Mundell
pages 508 - 519

View the article


Establishing a Role for the GTPase Ypt1p at the Late Golgi

Anthony Sclafani, Shuliang Chen, Felix Rivera-Molina, Karin Reinisch, Peter Novick and Susan Ferro-Novick
pages 520 - 532

View the article


Rab27a and Rab27b Regulate Neutrophil Azurophilic Granule Exocytosis and NADPH oxidase Activity by Independent Mechanisms

Jennifer L. Johnson, Agnieszka A. Brzezinska, Tanya Tolmachova, Daniela B. Munafo, Beverly A. Ellis, Miguel C. Seabra, Hong Hong and Sergio D. Catz
pages 533 - 547

View the article


Fluorescent Detection of Fluid Phase Endocytosis Allows for In Vivo Estimation of Endocytic Vesicle Sizes in Plant Cells with Sub-Diffraction Accuracy

Lars Gall, Razvan C. Stan, Alice Kress, Brigitte Hertel, Gerhard Thiel and Tobias Meckel
pages 548 - 559

View the article


Regulation of G-Protein Coupled Receptor Traffic by an Evolutionary Conserved Hydrophobic Signal

Tim Angelotti, David Daunt, Olga G. Shcherbakova, Brian Kobilka and Carl M. Hurt
pages 560 - 578

View the article