Notch receptors are clustered and trans-endocytosed by Delta ligand cells. Confocal micrograph of a Delta expressing cell (left) interacting with a Notch expressing cell (right). Following interaction with Delta (blue), cell surface Notch (yellow) is clustered at cell-cell interfaces. Notch extracellular domain is detected within Delta cells (green) indicative of trans-endocytosis. Endocytosis of ligand while bound to Notch may produce a force sufficient to pull Notch apart and activate signaling.
 
 
 
 
 
 

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Issue Table of Contents
 
 
May 2010 - Vol. 11 Issue 5 Page 579-720

Traffic Interchange Articles

Early Origin of Genes Encoding Subunits of Biogenesis of Lysosome-related Organelles Complex-1, -2 and -3

Verónica T. Cheli and Esteban C. Dell'Angelica
pages 579 - 586

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Original Articles

Legionella pneumophila Promotes Functional Interactions between Plasma Membrane Syntaxins and Sec22b

Kohei Arasaki and Craig R. Roy
pages 587 - 600

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Improvement in Lipid and Protein Trafficking in Niemann-Pick C1 Cells by Correction of a Secondary Enzyme Defect

Cecilia Devlin, Nina H. Pipalia, Xianghai Liao, Edward H. Schuchman, Frederick R. Maxfield and Ira Tabas
pages 601 - 615

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Regulation of ER–Golgi Intermediate Compartment Tubulation and Mobility by COPI Coats, Motor Proteins and Microtubules

Mónica Tomás, Emma Martínez-Alonso, José Ballesta and José A. Martínez-Menárguez
pages 616 - 625

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Rab33b and Rab6 are Functionally Overlapping Regulators of Golgi Homeostasis and Trafficking

Tregei Starr, Yi Sun, Ngozi Wilkins and Brian Storrie
pages 626 - 636

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Distinct Roles of Myosin Va in Membrane Remodeling and Exocytosis of Secretory Granules

Tanja Kögel, Rüdiger Rudolf, Erlend Hodneland, Andrea Hellwig, Sergei A. Kuznetsov, Florian Seiler, Thomas H. Söllner, João Barroso and Hans-Hermann Gerdes
pages 637 - 650

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ERp44 and ERGIC-53 Synergize in Coupling Efficiency and Fidelity of IgM Polymerization and Secretion

Margherita Cortini and Roberto Sitia
pages 651 - 659

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The G-protein Coupled Receptor Associated Sorting Protein GASP-1 Regulates the Signalling and Trafficking of the Viral Chemokine Receptor US28

Pia Tschische, Elisabeth Moser, Dawn Thompson, Henry F. Vischer, Gerald P. Parzmair, Veronika Pommer, Wolfgang Platzer, Thomas Schwarzbraun, Helmut Schaider, Martine J. Smit, Lene Martini, Jennifer L. Whistler and Maria Waldhoer
pages 660 - 674

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Cellular Internalization of Exosomes Occurs Through Phagocytosis

Du Feng, Wen-Long Zhao, Yun-Ying Ye, Xiao-Chen Bai, Rui-Qin Liu, Lei-Fu Chang, Qiang Zhou and Sen-Fang Sui
pages 675 - 687

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A Novel Syntaxin 6-Interacting Protein, SHIP164, Regulates Syntaxin 6-Dependent Sorting from Early Endosomes

Grant P. Otto, Minoo Razi, Joëlle Morvan, Frank Stenner and Sharon A. Tooze
pages 688 - 705

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AMN Directs Endocytosis of the Intrinsic Factor-Vitamin B12 Receptor Cubam by Engaging ARH or Dab2

Gitte Albinus Pedersen, Souvik Chakraborty, Amie L. Steinhauser, Linton M. Traub and Mette Madsen
pages 706 - 720

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