Notch receptors are clustered and trans-endocytosed by Delta ligand cells. Confocal micrograph of a Delta expressing cell (left) interacting with a Notch expressing cell (right). Following interaction with Delta (blue), cell surface Notch (yellow) is clustered at cell-cell interfaces. Notch extracellular domain is detected within Delta cells (green) indicative of trans-endocytosis. Endocytosis of ligand while bound to Notch may produce a force sufficient to pull Notch apart and activate signaling.
 
 
 
 
 
 

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Issue Table of Contents
 
 
June 2010 - Vol. 11 Issue 6 Page 721-876

Review Article

Emerging Roles of Ruk/CIN85 in Vesicle-Mediated Transport, Adhesion, Migration and Malignancy

Serhiy Havrylov, Maria Jolanta Redowicz and Vladimir L. Buchman
pages 721 - 731

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Traffic Interchange Articles

Modifications to the C-Terminus of Arf1 Alter Cell Functions and Protein Interactions

Xiaoying Jian, Margaret Cavenagh, James M. Gruschus, Paul A. Randazzo and Richard A. Kahn
pages 732 - 742

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Original Articles

Nucleolar Disruption Ensures Nuclear Accumulation of p21 upon DNA Damage

Neus Abella, Sonia Brun, Maria Calvo, Olga Tapia, Jason D. Weber, Maria T. Berciano, Miguel Lafarga, Oriol Bachs and Neus Agell
pages 743 - 755

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Nuclear Targeting of an Endosomal E3 Ubiquitin Ligase

Jeffrey P. Bocock, Stephanie Carmicle, Egbert Madamba and Ann H. Erickson
pages 756 - 766

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Novel PSI Domains in Plant and Animal H+-Inositol Symporters

Dorina Dotzauer, Susanne Wolfenstetter, Dorothee Eibert, Sabine Schneider, Petra Dietrich and Norbert Sauer
pages 767 - 781

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The Membrane-Associated Protein, Supervillin, Accelerates F-Actin-Dependent Rapid Integrin Recycling and Cell Motility

Zhiyou Fang, Norio Takizawa, Korey A. Wilson, Tara C. Smith, Anna Delprato, Michael W. Davidson, David G. Lambright and Elizabeth J. Luna
pages 782 - 799

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Limited Intermixing of Synaptic Vesicle Components upon Vesicle Recycling

Felipe Opazo, Annedore Punge, Johanna Bückers, Peer Hoopmann, Lars Kastrup, Stefan W. Hell and Silvio O. Rizzoli
pages 800 - 812

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Tec-Kinase-Mediated Phosphorylation of Fibroblast Growth Factor 2 is Essential for Unconventional Secretion

Antje D. Ebert, Mareike Laußmann, Sabine Wegehingel, Lars Kaderali, Holger Erfle, Jürgen Reichert, Johannes Lechner, Hans-Dietmar Beer, Rainer Pepperkok and Walter Nickel
pages 813 - 826

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The Role of GRASP65 in Golgi Cisternal Stacking and Cell Cycle Progression

Danming Tang, Hebao Yuan and Yanzhuang Wang
pages 827 - 842

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A Screen for Endocytic Motifs

Patrycja Kozik, Richard W. Francis, Matthew N. J. Seaman and Margaret S. Robinson
pages 843 - 855

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Regulation of Tight Junction Assembly and Epithelial Polarity by a Resident Protein of Apical Endosomes

Sarah D. McCarter, Debra L. Johnson, Khameeka N. Kitt, Carolyn Donohue, Alison Adams and Jean M. Wilson
pages 856 - 866

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Cell-Free Reconstitution of Multivesicular Body Formation and Receptor Sorting

Wei Sun, Thomas A. Vida, Natalie Sirisaengtaksin, Samuel A. Merrill, Phyllis I. Hanson and Andrew J. Bean
pages 867 - 876

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