Notch receptors are clustered and trans-endocytosed by Delta ligand cells. Confocal micrograph of a Delta expressing cell (left) interacting with a Notch expressing cell (right). Following interaction with Delta (blue), cell surface Notch (yellow) is clustered at cell-cell interfaces. Notch extracellular domain is detected within Delta cells (green) indicative of trans-endocytosis. Endocytosis of ligand while bound to Notch may produce a force sufficient to pull Notch apart and activate signaling.
 
 
 
 
 
 

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Issue Table of Contents
 
 
July 2010 - Vol. 11 Issue 7 Page 877-1015

Traffic Interchange Articles

Remote Origins of Tail-Anchored Proteins

Nica Borgese and Marco Righi
pages 877 - 885

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Original Articles

Differential Subcellular Distributions and Trafficking Functions of hnRNP A2/B1 Spliceoforms

Siew Ping Han, Lexie R. Friend, John H. Carson, George Korza, Elisa Barbarese, Michael Maggipinto, Jodie T. Hatfield, Joseph A. Rothnagel and Ross Smith
pages 886 - 898

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SKIP, the Host Target of the Salmonella Virulence Factor SifA, Promotes Kinesin-1-Dependent Vacuolar Membrane Exchanges

Audrey Dumont, Emmanuel Boucrot, Stéphanie Drevensek, Vanessa Daire, Jean-Pierre Gorvel, Christian Poüs, David W. Holden and Stéphane Méresse
pages 899 - 911

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Traffic of a Viral Movement Protein Complex to the Highly Curved Tubules of the Cortical Endoplasmic Reticulum

Shu-Chuan Lee, Chih-Hang Wu and Chao-Wen Wang
pages 912 - 930

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Efficient ER Exit and Vacuole Targeting of Yeast Sna2p Require Two Tyrosine-Based Sorting Motifs

Henri-François Renard, Didier Demaegd, Bérengère Guerriat and Pierre Morsomme
pages 931 - 946

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Pathogenesis of ER Storage Disorders: Modulating Russell Body Biogenesis by Altering Proximal and Distal Quality Control

Riccardo Ronzoni, Tiziana Anelli, Martina Brunati, Margherita Cortini, Claudio Fagioli and Roberto Sitia
pages 947 - 957

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S100A10-Mediated Translocation of Annexin-A2 to SNARE Proteins in Adrenergic Chromaffin Cells Undergoing Exocytosis

Emeline Umbrecht-Jenck, Valérie Demais, Valérie Calco, Yannick Bailly, Marie-France Bader and Sylvette Chasserot-Golaz
pages 958 - 971

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Secretory Granule Membrane Protein Recycles through Multivesicular Bodies

Nils Bäck, Chitra Rajagopal, Richard E. Mains and Betty A. Eipper
pages 972 - 986

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Lysosomal Targeting of the CLN7 Membrane Glycoprotein and Transport Via the Plasma Membrane Require a Dileucine Motif

Pieter Steenhuis, Stephanie Herder, Suyin Gelis, Thomas Braulke and Stephan Storch
pages 987 - 1000

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Modeling Fusion/Fission-Dependent Intracellular Transport of Fluid Phase Markers

Luis S. Mayorga and Emanuel M. Campoy
pages 1001 - 1015

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