Notch receptors are clustered and trans-endocytosed by Delta ligand cells. Confocal micrograph of a Delta expressing cell (left) interacting with a Notch expressing cell (right). Following interaction with Delta (blue), cell surface Notch (yellow) is clustered at cell-cell interfaces. Notch extracellular domain is detected within Delta cells (green) indicative of trans-endocytosis. Endocytosis of ligand while bound to Notch may produce a force sufficient to pull Notch apart and activate signaling.
 
 
 
 
 
 

Home

Aims and Scope

Editors

Contacts

Table of Contents

Article Search

Instructions to Authors

Submit an Article

Accepted Articles

Early View

Virtual Issues

Faculty of 1000

Supplemental Material

Cover Gallery

Subscribe

Etoc Alerts

Advertising

Links
 

 

  
Supplemental Material
 
 

Go back

Volume 5 issue 1 Januray 2004
A karyopherin α2 nuclear transport pathway is regulated by glucose in hepatic and pancreatic cells
Aurélia CASSANY, Ghislaine GUILLEMAIN, Christophe KLEIN, Véronique DALET, Edith BROT-LAROCHE and Armelle LETURQUE

Fig1 video: Visualization in living mhA3F cells of the change in GFP-karyopherin α2 location in response to glucose. The cells were placed in sequential 15 min incubations in glucose or glucose free medium as indicated in the upper left corner. Confocal microscopy images were acquired every 20s in time series. Arrows underline nuclear events.

View movie
View Movie

Back to top