Notch receptors are clustered and trans-endocytosed by Delta ligand cells. Confocal micrograph of a Delta expressing cell (left) interacting with a Notch expressing cell (right). Following interaction with Delta (blue), cell surface Notch (yellow) is clustered at cell-cell interfaces. Notch extracellular domain is detected within Delta cells (green) indicative of trans-endocytosis. Endocytosis of ligand while bound to Notch may produce a force sufficient to pull Notch apart and activate signaling.
 
 
 
 
 
 

Home

Aims and Scope

Editors

Contacts

Table of Contents

Article Search

Instructions to Authors

Submit an Article

Accepted Articles

Early View

Virtual Issues

Faculty of 1000

Supplemental Material

Cover Gallery

Subscribe

Etoc Alerts

Advertising

Links
 

 

  
Supplemental Material
 
 

Go back

Volume 7 issue 5 May 2006
Clathrin is Important for Normal Actin Dynamics and Progression of Sla2p Containing Patches During Endocytosis in Yeast
Thomas M. Newpher and Sandra K. Lemmon

SUPLEMENTARY MATERIAL:

Supplemental Movie S1. Time-lapse video of WT cells expressing Abp1p-mRFP and Sla2p-GFP (SL5185). Images were captured every 2 s with 500 ms exposures for a duration of four minutes.

Movie S1 (.mov)

Supplemental Movie S2. Time-lapse video of chc1 Δ cells expressing Sla2p-GFP and Abp1p-mRFP (SL5226). Images were captured every 2 s with 500 ms exposures for a duration of four minutes.

Movie S2 (.mov)

Back to top